• OP Labs formerly Oxford Peptides.
• Batch HPLC tested at 99%+ purity.
• Store in a cool dark place
• Sold for research purposes only.
• Contact us for Wholesale Orders.

Download COA here: NAD+_COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

NAD+

Synonyms / Designations: NAD+, Nicotinamide Adenine Dinucleotide (oxidised form), b-NAD+
CAS Number: 53-84-9
Molecular Formula: C21H27N7O14P2
Molar Mass: ~663.43 g/mol
Chemical Classification: Pyridine nucleotide coenzyme
Purity: 99 % (HPLC, typical)
Appearance: Clear liquid
Pack Size: 10ml
Storage: Store in a cool dark place. Discard 30 DAYS after opening.

Description & Mechanism

Nicotinamide adenine dinucleotide (NAD+) is an endogenous pyridine nucleotide that functions as a central redox cofactor and signalling molecule in cellular metabolism. In its oxidised form, NAD+ participates in electron transfer reactions fundamental to oxidative phosphorylation, glycolysis, and mitochondrial energy production.

In biochemical and cellular research systems, NAD+ is extensively studied for its role in redox balance, substrate availability for NAD+-dependent enzymes, and regulation of intracellular signalling pathways. These include sirtuins, poly(ADP-ribose) polymerases (PARPs), and cyclic ADP-ribose–generating enzymes involved in DNA repair, chromatin regulation, and calcium signalling. Experimental outcomes are influenced by intracellular NAD+/NADH ratios, compartmentalisation, and metabolic state of the model system.

Applications in Research

• Investigation of cellular redox metabolism and mitochondrial function
• Studies of NAD+-dependent enzymes including sirtuins and PARPs
• In vitro research on energy homeostasis and metabolic signalling pathways
• Use as a reference compound in enzymology and metabolic research

Handling & Stability

• Store in a cool dark place. Discard 30 DAYS after opening.
• Shelf life: 30 MONTHS from production

Specifications Summary

Purity: 100mg/ml
Appearance: Clear liquid
Chemical Type: Pyridine nucleotide coenzyme
Molecular Weight: ~663.43 g/mol
Storage: Store in a cool dark place. Discard 30 DAYS after opening.
Pack Size: 10ml

Precautions & Notes

• Experimental behaviour of NAD+ is influenced by pH, temperature, and redox environment.
• NAD+ is sensitive to hydrolysis under acidic or basic conditions.
• Appropriate controls are recommended when interpreting enzyme-dependent effects.
• Intended strictly for laboratory research use only; not for human or veterinary application.

References

Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science, 2015.
https://pubmed.ncbi.nlm.nih.gov/26785480/

Covarrubias A.J. et al. NAD⁺ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021.
https://www.nature.com/articles/s41580-020-00313-x

Rajman L. et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism, 2018.
https://pubmed.ncbi.nlm.nih.gov/29514064/

Braidy N., Liu Y. NAD⁺ therapy in age-related degenerative disorders: a benefit/risk analysis. Experimental Gerontology, 2020.
https://pubmed.ncbi.nlm.nih.gov/31606488/

Keywords :NAD+, Nicotinamide Adenine Dinucleotide, Pyridine Nucleotide, Redox Cofactor, Mitochondrial Metabolism, Enzymology, Metabolic Research