• OP Labs formerly Oxford Peptides
• Batch HPLC tested at 99%+ purity
• Store frozen long term or in fridge when ready to be used
• Sold for research purposes only
• Contact us for Wholesale Orders

Download COA here: TB-500_COA.pdf
Please note: if you have a different Batch ID, please contact us for the latest COA.

TB-500

Synonyms / Designations: TB-500, Thymosin Beta-4 Fragment, Synthetic Thymosin b4–Derived Peptide
CAS Number: 77591-33-4
Molecular Formula: C212H350N56O78S
Molecular Weight: ~4963.0 g/mol
Peptide Length: 43 amino acids
Peptide Type: Synthetic peptide derived from thymosin beta-4
Purity: 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

TB-500 is a synthetic peptide derived from the active region of thymosin beta-4, developed for experimental investigation of actin-binding dynamics, cell migration, and cytoskeletal organisation in controlled research settings.

In biochemical and cellular research models, thymosin beta-4–related peptides are studied for their interaction with G-actin, influencing actin polymerisation and cytoskeletal remodelling. Observed responses depend on peptide concentration, exposure duration, cell type, and experimental conditions.

Applications in Research

• Investigation of actin dynamics and cytoskeletal regulation
• In vitro studies of cell migration and cellular organisation
• Experimental models examining tissue structure and repair signalling
• Reference peptide in thymosin beta-4–related research

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide may be hygroscopic.
• Reconstitute in sterile water or appropriate buffered aqueous solution.
• Avoid vigorous agitation during dissolution.
• Filter sterilize if required.
• Aliquot and store reconstituted solutions at –20 °C or lower.
• Avoid repeated freeze–thaw cycles.

Precautions & Notes

• Experimental outcomes depend on cell type and assay conditions.
• Buffer composition, pH, and ionic strength may influence peptide stability.
• Appropriate controls are recommended.
• Intended strictly for laboratory research use only.

References

Gupta S., Paliczak A., Delgado D. Evidence-based indications of thymosin beta-4 for wound healing and tissue regeneration. Annals of the New York Academy of Sciences, 2021.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8228050/

Sosne G., Qiu P., Goldstein A.L., Wheater M. Biological activities of thymosin beta-4 defined by active sites in short peptide sequences. FASEB Journal, 2010.
https://iovs.arvojournals.org/article.aspx?articleid=2423767

Malinda K.M., Sidhu G.S., Mani H. et al. Thymosin beta-4 accelerates wound healing. Journal of Investigative Dermatology, 1999.
https://pubmed.ncbi.nlm.nih.gov/10469335/

Keywords: TB-500, Thymosin Beta-4, Synthetic Peptide, Actin Regulation, Cytoskeletal Dynamics, Research Peptide