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Download COA here: Thymosin_Alpha-1_COA.pdf
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Thymosin Alpha-1

Synonyms / Designations: Thymosin Alpha-1, Tα1, Thymosin α1, Thymalfasin
CAS Number: 62304-98-7
Molecular Formula: C129H215N33O55
Molecular Weight: ~3108.32 g/mol
Peptide Length: 28 amino acids
Peptide Type: Synthetic immunomodulatory peptide (thymic peptide analogue)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Thymosin Alpha-1 is a synthetic 28-amino-acid peptide corresponding to an active fragment of the endogenous thymic hormone prothymosin-α. It is widely used in experimental research to investigate immune system regulation, peptide–receptor interactions, and intracellular signalling pathways involved in innate and adaptive immunity.

In biochemical and cellular research systems, Thymosin Alpha-1 has been shown to modulate immune-related signalling pathways, including those associated with antigen presentation, cytokine expression, and T-cell differentiation. Experimental studies commonly examine its influence on toll-like receptor signalling, NF-κB activation, and interferon-related pathways. Observed molecular responses are dependent on concentration, exposure duration, and experimental model.

Applications in Research

• As a molecular probe for studying immune modulation and thymic peptide signalling.
• Investigation of innate and adaptive immune pathway regulation in cellular models.
• In vitro studies examining cytokine signalling, antigen presentation, and T-cell activation.
• Use as a reference peptide in immunology, inflammation, and host-defence research.

Specifications Summary

Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~3108.32 g/mol
Peptide Type: Synthetic thymic peptide analogue
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic.
• Reconstitute in sterile water or appropriate buffered aqueous solution.
• Avoid vigorous agitation during dissolution.
• Filter sterilize if required (e.g. 0.22 µm) prior to use.
• Aliquot and store reconstituted solutions at –20 °C or lower.
• Avoid repeated freeze–thaw cycles.

Precautions & Notes

• Experimental behaviour is influenced by immune cell type, receptor expression, concentration, and exposure duration.
• Buffer composition, pH, and ionic strength may affect peptide stability.
• Appropriate controls are recommended.
• Intended strictly for laboratory research use.

References

Goldstein A.L. et al. Thymosin alpha 1: biological activity and clinical applications. Annals of the New York Academy of Sciences, 2007.
https://pubmed.ncbi.nlm.nih.gov/17660844/

Romani L. et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance. Blood, 2004.
https://pubmed.ncbi.nlm.nih.gov/15026312/

Garaci E. et al. Thymosin alpha 1 in immune regulation. International Journal of Immunopharmacology, 1998.
https://pubmed.ncbi.nlm.nih.gov/9802921/

Keywords: Thymosin Alpha-1, Tα1, Thymalfasin, Immunomodulatory Peptide, Synthetic Thymic Peptide